唐毅

唐毅实验室采用多学科方法研究阿尔茨海默病（AD）及相关认知障碍，通过整合系统生物学、神经影像学、机器学习、基因分析和非药物干预手段来进行研究。

国际学术任职：

阿尔茨海默病协会非药物干预PIA项目主席，2016.12 - 2019.8

《阿尔茨海默病与痴呆》杂志审稿编辑，2023.1 - 至今

《阿尔茨海默病与痴呆》杂志高级副编辑，2014.10 - 2022.12

《阿尔茨海默病杂志》高级编辑，2021.01 - 至今

国内学术任职：

国家卫健委认知障碍疾病专科能力建设项目专家组组长，2021.9 - 至今

中华医学会神经病学分会青年委员会副主任委员，2017.4 - 至今

中华医学会神经病学分会痴呆与认知障碍学组委员，2020.9 - 至今

中国老年学和老年医学学会老年病学分会副会长，2024.8 - 至今

中国医师协会神经内科医师分会脑与脊髓学组副组长，2021.7 - 至今

北京医学会神经病学分会痴呆与认知障碍学组组长，2017.3 - 至今

《中华医学杂志》编委，2023.11 - 至今

《中华神经科杂志》编委，2021.1 - 至今

《中风与神经疾病杂志》编委，2019.5 - 至今

入选人才计划：

北京高校卓越青年科学家计划，2024.4

北京市属高校高水平科研创新团队，2023.2

青年北京学者，2022.9

北京市“登峰”人才计划，2022.5

教育部长江学者，2022.1

北京市杰出青年科学基金，2019.11

北京市高层次创新创业人才领军人才，2017.2

北京市百千万人才工程，2016.6

北京市高层次创新创业人才支持计划，2015.1

北京市优秀人才青年拔尖个人项目，2015.1

北京市卫生系统高层次卫生技术人才，2014.12

北京市科技新星，2010.12

获奖情况：

中华医学科技奖一等奖第一完成人，2023.12

首届北京市先进科技工作者，2023.7

首届中国十大杰出神经内科青年医师奖，2016.8

北京市科学技术进步奖一等奖第六完成人，2021.9

中华医学科技奖二等奖第六完成人，2021.3

1. Wang Z, Wang C, Wei T, Mi Y, Zhou S, Liu X, Jia J, Li L, Zhao G, Tang Y*. Impaired temporal coding associated with central auditory dysfunction and cognitive impairment in Alzheimer's disease. Sci Bull (Beijing). 2024 Oct 16:S2095-9273(24)00751-5. doi: 10.1016/j.scib.2024.10.012.

2. Shen H, Yu Y, Wang J, Nie Y, Tang Y*, Qu M*. Plasma lipidomic signatures of dementia with Lewy bodies revealed by machine learning, and compared to alzheimer's disease. Alzheimers Res Ther. 2024 Oct 15;16(1):226. doi: 10.1186/s13195-024-01585-7.

3. Yang K, Yang X, Yin P, Zhou M, Tang Y*. Temporal trend and attributable risk factors of Alzheimer's disease and other dementias burden in China: Findings from the Global Burden of Disease Study 2021. Alzheimers Dement. 2024 Sep 23. doi: 10.1002/alz.14254.

4. Wang T, Yan S, Shan Y, Xing Y, Bi S, Chen Z, Xi H, Xue H, Qi Z, Tang Y*, Lu J*. Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer's Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study. J Alzheimers Dis. 2024 Sep 12. doi: 10.3233/JAD-240400.

5. Tang Y*, Xing Y, Sun L, Wang Z, Wang C, Yang K, Zhu W, Shi X, Xie B, Yin Y, Mi Y, Wei T, Tong R, Qiao Y, Yan S, Wei P, Yang Y, Shan Y, Zhang X, Jia J, Teipel SJ, Howard R, Lu J, Li C, Zhao G. TRanscranial AlterNating current stimulation FOR patients with mild Alzheimer's Disease (TRANSFORM-AD): a randomized controlled clinical trial. Alzheimers Res Ther. 2024 Sep 12;16(1):203. doi: 10.1186/s13195-024-01570-0.

6. Liu L, Wang H, Xing Y, Zhang Z, Zhang Q, Dong M, Ma Z, Cai L, Wang X, Tang Y*. Dose-response relationship between computerized cognitive training and cognitive improvement. NPJ Digit Med. 2024 Aug 15;7(1):214. doi: 10.1038/s41746-024-01210-

7. Liu Y, Wang Z, Wei T, Zhou S, Yin Y, Mi Y, Liu X, Tang Y*. Alterations of Audiovisual Integration in Alzheimer's Disease. Neurosci Bull. 2023 Dec;39(12):1859-1872. doi: 10.1007/s12264-023-01125-7.

8. Liu LY, Xing Y, Zhang ZH, Zhang QG, Dong M, Wang H, Cai L, Wang X, Tang Y*. Validation of a Computerized Cognitive Training Tool to Assess Cognitive Impairment and Enable Differentiation Between Mild Cognitive Impairment and Dementia. J Alzheimers Dis. 2023;96(1):93-101. doi: 10.3233/JAD-230416.

9. Yang H, Qin Q, Wang M, Yin Y, Li R, Tang Y*. Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease. Cell Immunol. 2023 Sep-Oct;391-392:104743. doi: 10.1016/j.cellimm.2023.104743.

10. Teipel S, Tang Y, Boccardi M. Predicting cognitive decline in older people by structural and molecular imaging. Curr Opin Neurol. 2023 Aug 1;36(4):253-263. doi: 10.1097/WCO.0000000000001172.

11. Qin Q, Qu J, Yin Y, Liang Y, Wang Y, Xie B, Liu Q, Wang X, Xia X, Wang M, Zhang X, Jia J, Xing Y*, Li C*, Tang Y*. Unsupervised machine learning model to predict cognitive impairment in subcortical ischemic vascular disease. Alzheimers Dement. 2023 Feb 14. doi: 10.1002/alz.12971.

12. Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng Z*, Liu CM*. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med. 2022;e15795. doi:10.15252/emmm.202215795.

13. Lutz MW, Khachaturian AS, Zetterberg H, Blennow K, Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, Greenberg BD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide. Alzheimers Dement. 2022 Sep;18(9):1595-1601. doi: 10.1002/alz.12772.

14. Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y*, Liu CM*. The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080. doi: 10.1016/j.stemcr.2022.07.004.

15. Li RY, Qin Q, Yang HC, Wang YY, Mi YX, Yin YS, Wang M, Yu CJ, Tang Y*. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Mol Neurodegener. 2022 Jun 3;17(1):40. doi: 10.1186/s13024-022-00542-y.

16. Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, HeBD, He XC, Du HZ, Yang HC, Tang Y*, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning and memory. Mol Psychiatry. 2022 Jul; 27(7):2999-3009. doi: 10.1038/s41380-022-01576-w.

17. Mi Y, Qin Q, Xing Y, Tang Y*. Capgras Syndrome as the Core Manifestation of Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2022 Mar 2. doi: 10.3233/JAD-215565.

18. Teipel S, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller S, Kilimann I, Tang Y. Alzheimer's disease - standard of diagnosis, treatment, care, and prevention. J Nucl Med. 2022 Feb 10:jnumed.121.262239. doi: 10.2967/jnumed.121.262239.

19. Xing Y, Yang J, Zhou A, Wang F, Tang Y*, Jia J*. Altered brain activity mediates the relationship between white matter hyperintensity severity and cognition in older adults. Brain Imaging Behav. 2021 Oct 20. doi: 10.1007/s11682-021-00564-y.

20. Wang C#, Wang Z#, Xie B, Shi X, Yang P, Liu L, Qu T, Qin Q, Xing Y, Zhu W, Teipel SJ, Jia J, Zhao G*, Li L*, Tang Y*. Binaural processing deficit and cognitive impairment in Alzheimer’s disease. Alzheimers Dement. 2022;18(6):1085-1099. doi:10.1002/alz.12464DOI: 10.1002/alz.12464.

21. Tang Y*, Xing Y, Cui L, Wu C, Wen X, Song H, Wu L, Chang H, Song J, Wang Y*, Zhao G*. Neurology practice during the COVID-19 outbreak and post-pandemic era: experiences and challenges. Eur J Neurol. 2020;27(12):e81-e83. doi:10.1111/ene.14445

22. Xing Y, Zhu Z, Du Y, Zhang J, Qu Q, Sun L, Li Y, Guo Y, Peng G, Liu Y, Yu Y, Qiao Y, Xie B, Shi X, Lu J, Jia J, Tang Y*. The Efficacy of Cognitive training in patients with Amnestic mild cognitive impairment (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial. J Alzheimers Dis. 2020;75(3):779-787.

23. Xing Y, Wei P, Wang C, Shan Y, Yu Y, Qiao Y, Xie B, Shi X, Zhu Z, Lu J, Zhao G, Jia J, Tang Y*. TRanscranial AlterNating current Stimulation FOR patients with Mild Alzheimer's Disease (TRANSFORM-AD study): Protocol for a randomized controlled clinical trial. Alzheimers Dement (N Y). 2020;6(1):e12005.

24. Tang Y#*, Xing Y#, Zhu Z#, He Y, Li F, Yang J, Liu Q, Li F, Teipel SJ, Zhao G*, Jia J*. The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial. Alzheimers Dement. 2019;15(5):605-614.

25. Tang Y*, Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019;15(1):168-171.