高子龙

北京脑所致力于整合基础研究、临床研究和应用研究，实现新机制、新靶点、新技术的“bench to bedside”。动物行为学表型分析是神经疾病模型分析、神经环路机制研究、药物筛选和安全性测试等研究的核心技术手段。行为分析中心将结合最新行为学表型分析研究进展，充分利用脑机接口技术、深度学习算法、神经网络架构等新技术的发展趋势，建立大规模、自动化、标准化的智能动物行为监测、记录和分析平台。

同时，我们也积极与脑科学研究相关的课题组进行合作，包括脑科学研究所、北京及周边地区的研究团队，逐步建立起各类神经疾病的行为数据库，为神经疾病检测、行为表型分析以及药物筛选等提供高通量和标准化的解决方案。

1. Cao S^#, Wu Y^#, Gao Z^#, Tang J, Xiong L, Hu J, Li C. Automated phenotyping of postoperative delirium-like behavior reveals the therapeutic efficacy of dexmedetomidine. Communications Biology (Inpress, ^#Co-first author)
2. Pan Q^#, Guo S^#, Chen M, Su X, Gao Z, Wang Q, Xu T, Liu M, Hu J. Representation and control of pain and itch by distinct prefrontal neural ensembles. Neuron 2023. Epub 2023/05/23. doi: 10.1016/j.neuron.2023.04.032
3. Lu C^#, Zhu X^#, Feng Y^#, Ao W, Li J, Gao Z, Luo H, Chen M, Cai F, Zhan S, Li H, Sun W, Hu J. Atypical antipsychotics antagonize GABA(A) receptors in the ventral tegmental area GABA neurons to relieve psychotic behaviors. Molecular Psychiatry. 2023. Epub 2023/02/09. doi: 10.1038/s41380-023-01982-8
4. Lu C^#, Feng Y, Li H, Gao Z, Zhu X, Hu J. A preclinical study of deep brain stimulation in the ventral tegmental area for alleviating positive psychotic-like behaviors in mice. Frontiers in Human Neuroscience. 2022;16:945912. Epub 2022/08/30. doi: 10.3389/fnhum.2022.945912.
5. Zeng Y^#, Luo H^#, Gao Z, Zhu X, Shen Y, Li Y, Hu J, Yang J. Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine. iScience. 2021;24(3):102213. doi: 10.1016/j.isci.2021.102213.
6. Guo J^#, Ran M^#, Gao Z, Zhang X, Wang D, Li H, Zhao S, Sun W, Dong H, Hu J. Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia. eBioMedicine. 2021;65:103272. doi: 10.1016/j.ebiom.2021.103272.
7. Gao Z^#, Wang H^#, Lu C, Lu T, Froudist-Walsh S, Chen M, Wang XJ, Hu J, Sun W. The neural basis of delayed gratification. Science Advances. 2021;7(49):eabg6611. doi: 10.1126/sciadv.abg6611. (^#Co-first author)
8. Li J^#, Lu C^#, Gao Z, Feng Y, Luo H, Lu T, Sun X, Hu J, Luo Y. SNRIs achieve faster antidepressant effects than SSRIs by elevating the concentrations of dopamine in the forebrain. Neuropharmacology. 2020;177:108237. doi: 10.1016/j.neuropharm.2020.108237.
9. Wang F^#, Zhang J, Yuan Y, Chen M, Gao Z, Zhan SL, Fan C, Sun W, Hu J. Salience processing by glutamatergic neurons in the ventral pallidum. Science Bulletin. 2020;65(5):389-401. doi: 10.1016/j.scib.2019.11.029.
10. Gao Z^#, Wu R^#, Chen C^#, Wen B^#, Liu Y, Lu W, Chen N, Feng J, Fan R, Wang D, Cui S, Wang JH. Coactivations of barrel and piriform cortices induce their mutual synapse innervations and recruit associative memory cells. Brain Research. 2019:146333. doi: 10.1016/j.brainres.2019.146333. (^#Co-first author)
11. Yan F^#, Gao Z^#, Chen P^#, Huang L^#, Wang D, Chen N, Wu R, Feng J, Cui S, Lu W, Wang JH. Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory. Neural Plasticity. 2016;2016:5648390. doi: 10.1155/2016/5648390. (^#Co-first author)
12. Gao Z^#, Chen L^#, Fan R^#, Lu W, Wang D, Cui S, Huang L, Zhao S, Guan S, Zhu Y, Wang JH. Associations of Unilateral Whisker and Olfactory Signals Induce Synapse Formation and Memory Cell Recruitment in Bilateral Barrel Cortices: Cellular Mechanism for Unilateral Training Toward Bilateral Memory. Frontiers in Cellular Neuroscience. 2016;10:285. doi: 10.3389/fncel.2016.00285. (^#Co-first author)
13. Wang D^#, Zhao J^#, Gao Z^#, Chen N, Wen B, Lu W, Lei Z, Chen C, Liu Y, Feng J, Wang JH. Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontiers in Cellular Neuroscience. 2015;9:320. doi: 10.3389/fncel.2015.00320. (^#Co-first author)
14. Zhang G^#, Gao Z^#, Guan S, Zhu Y, Wang JH. Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs. Molecular Brain. 2013;6:2. doi: 10.1186/1756-6606-6-2. (^#Co-first author)
15. Ye B^#, Huang L^#, Gao Z, Chen P, Ni H, Guan S, Zhu Y, Wang JH. The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. PloS one. 2012;7(8):e41986. doi: 10.1371/journal.pone.0041986.