李雅堂

人类约一半的脑区处理跟视觉相关的信息。视觉处理始于视网膜：视网膜神经环路处理了大量涌入眼中的信息（~10亿 bits/sec）。视网膜将处理过的信息输送到两个视觉中心：上丘—一个进化中保守的结构；视皮层—一个在哺乳动物中新出现的结构。视觉处理不仅可以使我们对所看到的内容产生连贯的感知，而且可以提取出极少量的特定信息（~20 bits/sec）来指导我们的行为。我们实验室整合全细胞膜片钳技术、双光子和大视场成像，基于光遗传学或者化学遗传学的功能性扰动、神经建模和行为量化分析，来探索视觉处理的神经机制和计算原理。

我们的研究兴趣包括：

1)  视觉信息在细胞群水平的编码及其神经环路；

2)  视觉注意的神经机制；

3)  视觉诱发的决策行为的神经环路；

4）生物启发的计算机视觉。理解视觉处理的神经机制不仅可以揭示脑工作的原理，而且有助于对视觉疾病的理解和启发新的人工智能算法。

2019 – 2024   NIH Pathway to Independence Award (K99/R00)

2015 – 2018   Helen Hay Whitney Postdoctoral Fellowship

2013   国家优秀自费留学生奖学金

2013   Academic Professional Development Award

2011   Zach Hall Travel Award

* equal contribution

# corresponding author

1. Li YT^#, Turan Z, and Meister M^# (2020) Functional architecture of motion direction in the mouse superior colliculus. Current Biology: https://doi.org/10.1016/j.cub.2020.06.023

2. Li YT, Fang Q, Zhang LI, and Tao HW^# (2018) Spatial Asymmetry and Short-Term Suppression Underlie Direction Selectivity of Synaptic Excitation in the Mouse Visual Cortex. Cerebral Cortex 28: 2059–2070.

3. Ibrahim LA, Mesik L, Ji XY, Fang Q, Li HF, Li YT, Zingg B, Zhang LI^#, and Tao HW^# (2016) Cross-modality sharpening of visual cortical processing through layer-1-mediated inhibition and disinhibition. Neuron 89: 1031–1045.

4. Li YT, Liu BH, Chou XL, Zhang LI, and Tao HW^# (2015) Synaptic Basis for Differential Orientation Selectivity between Complex and Simple Cells in Mouse Visual Cortex. J Neurosci 35: 11081–11093.

5. Li YT, Liu BH, Chou XL, Zhang LI, and Tao HW^# (2015) Strengthening of Direction Selectivity by Broadly Tuned and Spatiotemporally Slightly Offset Inhibition in Mouse Visual Cortex. Cerebral Cortex 25: 2466–2477.

6. Zhou M, Li YT, Yuan W, Tao HW, and Zhang LI^# (2014) Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus. J Neurophysiol 113: 1358–1368.

7. Li LY, Ji XY, Liang F, Li YT, Xiao Z, Tao HW^#, and Zhang LI^# (2014) A feedforward inhibitory circuit mediates lateral refinement of sensory representation in upper layer 2/3 of mouse primary auditory cortex. J Neurosci 34: 13670–13683.

8. Tao HW^#, Li YT, and Zhang LI^# (2014) Formation of excitation-inhibition balance: inhibition listens and changes its tune. Trends Neurosci 37:528–530.

9. Li YT, Ibrahim LA, Liu BH, Zhang LI, and Tao HW^# (2013) Linear Transformation of Thalamocortical input by Intracortical Excitation. Nat Neurosci 16: 1324–1330. (Featured with a preview in Nat Neurosci)

10. Li L.Y., Li YT, Zhou Mu, Tao HW, and Zhang LI^# (2013) Intracortical Multiplication of Thalamocortical Signals in Mouse Auditory Cortex. Nat Neurosci 16: 1179–1181. (Featured with a preview in Nat Neurosci)

11. Ma WP^*, Li YT^*, and Tao HW^# (2013) Down-regulation of Cortical Inhibition Mediates Ocular Dominance Plasticity During the Critical Period. J Neurosci 33: 11276–11280.

12. Li YT, Ma W.P., Li LY, Ibrahim LA, Wang SZ, and Tao HW^# (2012) Broadening of Inhibitory Tuning Underlies Contrast-Dependent Sharpening of Orientation Selectivity in Mouse Visual Cortex. J Neurosci 32:16466–16477.

13. Li YT, Ma WP, Pan CJ, Zhang LI, and Tao HW^# (2012) Broadening of Cortical Inhibition Mediates Developmental Sharpening of Orientation Selectivity. J Neurosci 32:3981–3991.

14. Liu BH^*, Li YT^*, Ma WP, Pan CJ, Zhang LI, and Tao HW^# (2011) Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells. Neuron 71:542–554.

15. Ma WP^*, Liu BH^*, Li YT, Huang ZJ, Zhang LI, and Tao HW^# (2010) Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. J Neurosci 30: 14371–14379.

16. Liu BH, Li P.Y., Sun YJ, Li YT, Zhang LI^#, and Tao HW^# (2010) Intervening inhibition underlies simple-cell receptive field structure in visual cortex. Nature Neuroscience 13: 89–96.

17. Liu BH, Li PY, Li YT, Sun YJ, Yanagawa Y., Obata K, Zhang LI^#, and Tao HW^# (2009) Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. J Neurosci 29: 10520–10532.

18. Li YT, Qiu JH, Yang Z, Johns EJ, and Zhang T^# (2008) Long-range correlation of renal sympathetic nerve activity in both conscious and anesthetized rats. J Neurosci Methods 172: 131–136.