石玮

研究员

Ph.D.

神经系统和肿瘤的互作调控。

shiwei@cibr.ac.cn

https://shilab.cibr.ac.cn/yjfx/index.htm

教育经历

2011 – 2017 美国康奈尔大学威尔医学院，神经学，博士

2007 – 2011 四川大学生命科学学院，学士

工作经历

2025 至今北京脑科学与类脑研究所，研究员

2021 – 2025 北京脑科学与类脑研究所，青年学者

2017 – 2020 美国纪念斯隆凯特琳癌症中心，免疫学系，博士后

研究概述

我们感兴趣的问题有：神经系统如何识别外周肿瘤刺激？中枢神经系统是否参与调控肿瘤恶病质？外周神经信号是否参与调控体部肿瘤的发生发展及肿瘤免疫微环境？我们通过整合神经生物学和免疫学的实验技术，包括胚胎电转、神经环路示踪、化学遗传学、小鼠行为学、新一代测序、多通道流式细胞术等，研究神经系统和肿瘤的互作调控。

荣誉、奖励、学术兼职

发表文章

1. Shi Y.*, Sun Q.*, Jia F., Xie X., Zhou X., Guo R., Zeng Y., Chen S., Guo Z., Sun W., Guo T., Xia Y., Li W., Zhang L., Shi W.^CA & Yu Y.^CA (2025) Oncogenic fusions converge on shared mechanisms in initiating astroblastoma. Nature. 643, 551–561. (* Co-first author)

2. Do M.H.*, Shi W. *, Ji L. *, Ladewig E., Zhang X, Srivastava R.M., Capistrano K.J., Edwards C., Malik I., Nixon B.G., Stamatiades E.G., Liu M., Li S., Li P., Chou C., Xu Ke., Hsu T, Wang X, Chan T.A., Leslie C.S., Li MO. (2023) Reprogramming tumor-associated macrophages to outcompete endovascular endothelial progenitor cells and suppress tumor neoangiogenesis. Immunity 56(11): 2555-2569. (* Co-first author)

3. Zhang X, Li S, Malik I, Do MH, Ji L, Chou C, Shi W, Capistrano KJ, Zhang J, Hsu TW, Nixon BG, Xu K, Wang X, Ballabio A, Schmidt LS, Linehan WM, Li MO. (2023) Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature 619(7970):616-623.

4. Liu M., Kuo F., Capistrano K.J., Kang D., Nixon B.G., Shi W., Chou C., Do M.H., Stamatiades E.G., Gao S., Li S., Chen Y., Hsieh J.J., Hakimi A.A., Taniuchi I., Chan T.A., Li MO. (2020) TGF-β Suppresses Type 2 Immunity to Cancer. Nature 587(7832):115-120. (PMID: 33087928)

5. Li S., Liu M., Do M.H., Chou C., Stamatiades E.G., Nixon B.G., Shi W., Zhang X., Li P., Gao S., Capistrano K.J., Xu H., Cheung N-K. V., Li MO. (2020) Cancer Environment Immunotherapy via Targeted TGF-β Signaling Blockade in Helper T Cells. Nature 587(7832):121-125. (PMID: 33087933)

6. Shi W., Xinyu A., Han Z., Tang X., Li Z., Zhong H., Mao T., Huang K., and Shi S.-H. (2017) Ontogenetic Establishment and Order-specific Nuclear Organization in the Mammalian Thalamus. Nat. Neurosci. 20(4):516-528. (PMCID: PMC5374008)

7. Legue E., Gottshall J.L., Jaumouille E., Rosello-Diez A., Shi W., Barraza L.H., Washington S., Grant R.L., Joyner A.L. (2016) Differential Timing of Granule Cell Production during Cerebellum Development Underlies Generation of the Foliation Pattern. Neural Dev. 11: 17. (PMCID: PMC5017010)

8. Tan X., Liu W.A., Zhang X., Shi W., Ren S., Li Z., Brown K.N., Shi S.-H. (2015) Vascular Regulation of Neocortical Interneuron Production. Dev. Cell 36: 624-638. (PMID: 27003936)

9. Xu H., Han Z., Gao P., He S., Li Z., Shi W., Kodish O., Shao W., Brown K.N., Huang K., Shi S.-H. (2014) Distinct Lineage-Dependent Structural and Functional Organization of the Hippocampus. Cell 157: 1552–1564. (PMCID: PMC4120073)

10. Sultan K.T.*, Shi W.*, Shi S.-H. (2014) Clonal Origins of Neocortical Interneurons. Curr. Opin. Neurobiol. 26:125–131. (Review article, * Co-first author) (PMCID: PMC4024342)