井淼

生物体通过多系统之间的协同作用维持其正常的生理功能。在其中，神经递质、激素等化学小分子在细胞间信息沟通和交流中起到不可或缺的作用。我们课题组试图通过开发新的技术手段，为寻找新的信息传递分子、实时观测小分子动态变化以及最终解析其在特定生理调控，尤其是神经-免疫相互作用中的功能提供新的途径。

1: Jing, M. *, Zhang, P. *, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*CA. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737

2: Sun, F. *, Zeng, J. *, Jing, M. *, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.CA (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496

3: Wang, H., Jing, M., & Li, Y.CA (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178

4: Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.CA (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron, 102(4), 745-761

5: Wu, Z.*, Feng, J.*, Jing, M., & Li, Y.CA (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing, vol. 10865, p. 108650N. International Society for Optics and Photonics

6. Jing, M., Zhang, Y., Wang, H. & Li, Y.CA (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, 50: 171-178

7. Jing, M.CA, Li, YX., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Zou, J., Trinh, S., Wu, R., Zhang, S., Pan, S., Hires, S.A., Xu, M., Li, H., Saksida, L., Prado, V., Bussey, T., Prado, M.A., Chen, L., Cheng, H.& Li, Y.CA (2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, 17, 1139-1146

8. Zhu, P.K., Zheng, WS., Zhang, P., Jing, M., Borden, P.M., Ali, F., Guo, K., Feng, J., Marvin, J., Wang, Y., Wan, J., Gan, L., Kwan, A., Lin, L., Loren, L., Li, Y., Zhang, Y.CA (2020). Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors. Nano Letters 20,6,4073-4083

9. Crouse, R., Kim, K., Batchelor, H.M., Girardi, E., Kamaletdinova, R., Chan, J., Rajebhosale, P., Pittenger, S., Role, L.W., Talmage, D.A., Jing, M., Li, Y., Gao, X., Mineur, Y., Picciotto, M.R.CA (2020). Acetylcholine is released in the basolateral amydala in response to predictors of reward and enhances the learning of cue-reward contingency. eLife, 9:e57335

10. Zhu, R., Zhang, G., Jing, M., Han, Y., Li, J., Zhao, J., Li, Y., & Chen, P. R.CA (2021). Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nature Communications, 12(1), 581

11. Sethuramanujam, S., Matsumoto, A., deRosenroll, G., Murphy-Baum, B., McIntosh, J. M., Jing, M., Li, Y., Berson, D., Yonehara, K.CA, & Awatramani, G. B.CA (2021). Rapid multi-directed cholinergic transmission in the central nervous system. Nature Communications, 12,1374