相杨

高级研究员

Ph.D.

神经系统的损伤修复

yang.xiang@cibr.ac.cn

教育经历

1995-1999 南京大学，生物化学学士

1999-2003 中国科学院神经科学研究所，神经生物学博士

工作经历

2003-2004 中国科学院神经科学研究所，研究助理

2004-2012 加州大学旧金山分校，博士后

2012-2025 马塞诸塞州立大学医学院，助理教授，副教授，长聘副教授（tenure）

2026-至今北京脑科学与类脑研究所，高级研究员

研究概述

相杨实验室利用小鼠，大鼠，以及果蝇作为研究模型，聚焦两个研究领域：

1、神经系统的发育，损伤，以及损伤后功能修复；

2、机械感受。

研究方法包括遗传学，行为学，在体神经系统活性记录，钙离子成像，空间代谢组MALDI ，iPS细胞培养等。

主要研究方向如下：

1、以大小鼠脊髓损伤为模型，探讨中枢神经损伤后轴突再生和死亡的机制，以及功能修复的新方案；

2、以大小鼠为模型，探讨疾病引起外周神经病变和感觉异常的机制；

3、以果蝇为遗传学模型，研究神经元和胶质细胞的相互作用。

荣誉、奖励、学术兼职

2023-25 ad hoc and then standing member, NIH Neurobiology of Pain Study Section

2023-27 Wings for Life––Spinal Cord Research Foundation Award

2022-25 Whitehall Foundation Research Award

2022 Dan and Diane Riccio Neuroscience Award

2014-17 Human Frontier Science Program Young Investigator Award

2013 Worcester Foundation Award

2004-07 Human Frontier Science Program Long-term Fellowship

2005 全国优秀博士论文

2004 中国科学院优秀博士学位论文

2003 中国科学院院长奖

发表文章

Superscripts ^p, ^g, ^u, and ^ra denote postdoctoral fellows, graduate students, undergraduate students, and research assistants from our laboratory, respectively. Asterisks (*) indicate corresponding author(s).

1. Gong J^p, Nirala N, Chen J, Wang F^g, Gu P^p, Wen Q, Ip YT*, Xiang Y* (2023) TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila. Science Advances http://doi.org/10.1126/sciadv.adc9660.

2. Wang F^g, Ruppell KT^g, Zhou S, Qu Y, Gong J^p, Shang Y^g, Wu J, Liu X, Diao W, Li Y*, Xiang Y* (2023) Gliotransmission and adenosine signaling promote axon regeneration. Developmental Cell. https://doi.org/10.1016/j.devcel.2023.03.007. News report: https://www.umassmed.edu/news/news-archives/2023/09/study-shows-neuron-glia-crosstalk-important-factor-in-axon-regeneration/

3. Gong J^p, Chen J, Gu P^p, Shang Y^g, Ruppell KT^g, Yang Y^ra, Wang F^g, Wen Q*, Xiang Y* (2022) Shear stress activates nociceptors to drive Drosophila mechanical nociception. Neuron. doi: 10.1016/j.neuron.2022.08.015. PMID: 36087585. News report:

https://medicalxpress.com/news/2022-12-hints-potentially-crucial-role-stress.html

4. Gu P^p, Wang F^g, Shang Y^g, Liu J, Gong J^p, Xie W, Han J, Xiang Y* (2022) Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2113645119. PMID: 35294287.

5. Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT^g, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE (2020) TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca²⁺. Nat Commun. doi: 10.1038/s41467-020-16411-5. PMID: 32471994.

6. Gu P^p, Gong J^p, Shang Y^g, Wang F^g, Ruppell KT^g, Ma Z, Sheehan AE, Freeman MR, Xiang Y* (2019) Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Curr Biol. doi: 10.1016/j.cub.2019.09.070. PMID: 31735672.

7. Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F^g, Li T, Thompson-Peer KL, Gong J^p, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN (2019) The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. DOI: 10.1016/j.neuron.2019.01.050. PMID: 30819546.

8. Yan C, Wang F^g, Peng Y, Williams CR, Jenkins B, Wildonger J, Kim HJ, Perr JB, Vaughan JC, Kern ME, Falvo MR, O'Brien ET 3rd, Superfine R, Tuthill JC, Xiang Y, Rogers SL, Parrish JZ (2018) Microtubule Acetylation Is Required for Mechanosensation in Drosophila. Cell Rep. DOI: 10.1016/j.celrep.2018.09.075. PMID: 30355484.

9. Guntur AR, Gou B, Gu P^p, He R, Stern U, Xiang Y, Yang CH (2017) H2O2-Sensitive Isoforms of Drosophila melanogaster TRPA1 Act in Bitter-Sensing Gustatory Neurons to Promote Avoidance of UV During Egg-Laying. Genetics. doi: 10.1534/genetics.116.195172. PMID: 27932542.

10. Wu X, Zhang Y, Ruppell KT^g, Bilsel O, Li Z, Lee H, Zhang Z, Li D, Fan W, Duan C, Chan EM, Lois C, Xiang Y, Han G (2016) Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano. doi: 10.1021/acsnano.5b06383. PMID: 26736013.

11. Im SH, Takle K^g, Jo J, Babcock DT, Ma Z, Xiang Y, Galko MJ (2015) Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. Elife. 2015 doi: 10.7554/eLife.10735. PMID: 26575288.

12. Guntur AR, Gu P^p, Takle K^g, Chen J^u, Xiang Y*, Yang CH* (2015) Drosophila TRPA1 isoforms detect UV light via photochemical production of H2O2. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1514862112. PMID: 26443856.

13. Yang L, Li R, Kaneko T, Takle K^g, Morikawa RK, Essex L, Wang X, Zhou J, Emoto K, Xiang Y, Ye B (2014) Trim9 regulates activity-dependent fine-scale topography in Drosophila. Curr Biol. doi: 10.1016/j.cub.2014.03.041. PMID: 24746793.

14. Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L., Meltzer, S., Jan, L.Y., & Jan, Y.N. (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493: 221-225. PMC3917554

15. Yuan, Q., Xiang, Y., Yan, Z.Q., Han, C., Jan, L.Y., & Jan, Y.N. (2011). Light induced structural and functional plasticity in Drosophila larval visual System. Science 333: 1458-1462. PMC4114502

16. Xiang, Y., Yuan, Q., Vogt, N., Looger, L. L., Jan, L. Y. and Jan, Y. N. (2010). Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468: 921-926. PMC3026603 (Research Article). News and Views article in Nature: 468: 900-901

17. Yang, C., Rumpf, S., Xiang, Y., Gordon, M. D., Song, W., Scott, K., Jan, L. Y. and Jan, Y. N. (2009). Control of post-mating behavior switch in Drosophila females by internal sensory neurons. Neuron 61:519-526. PMC2748846

18. Xiang, Y., Li, Y., Zhang, Z., Cui, K., Wang, S., Yuan, X., Wu, C., Poo, M. and Duan, S. (2002) Nerve growth cone guidance mediated by G protein-coupled receptors. Nature Neuroscience 5:843-848.