殷杰

研究员

Ph.D.

中枢神经系统G蛋白偶联受体的结构与功能研究。

jyin(at)cibr.ac.cn

教育经历

2005-2010 中国科学院生物物理研究所，博士

2000-2004 武汉大学，生物学，本科

工作经历

2022.4至今北京脑科学与类脑研究所，研究员

2019.3-2022.2 美国德克萨斯大学西南医学中心，Instructor

2017.3-2019.8 美国德克萨斯大学西南医学中心，Assistant instructor

2011.5-2017.3 美国德克萨斯大学西南医学中心，博士后

研究概述

G蛋白偶联受体介导了人体内多数神经递质和激素的信号通路，以及传递视觉、嗅觉与味觉刺激。也是目前大约1/3的药物的作用靶点。获取三维结构信息不仅有助于阐明受体与配体或药物分子的结合原理和激活机制，还能有利于基于结构的合理药物设计。

目前，我们致力于精神疾病或癌症相关以及感应嗅觉与味觉刺激的G蛋白偶联受体的结构与功能研究。我们综合应用结构生物学、生物物理学、分子药理学以及计算化学等方法阐明G蛋白偶联受体介导信号的分子机制，以及基于此机制寻找与开发具有治疗潜力的配体小分子或者抗体。

发表文章

^{* Contribute equally # Co-correspondence}

^1.^{Jie Yin*}^{, Yanyong Kang*, Aaron McGrath*, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach#, Jef K. De Brabander#, Daniel M. Rosenbaum#. Molecular mechanism of the wake-promoting agent TAK-925.}^{Nature Communications}^{(2022, accepted)}

^{2. Jan Hellmann*, Matthäus Drabek*,}^{Jie Yin*,}^{Jakub Gunera, Theresa Pröll, Frank Kraus, Christopher J. Langmead, Harald Hübner, Dorothee Weikert, Peter Kolb#, Daniel M. Rosenbaum#, and Peter Gmeiner#. Structure-based development of a subtype-selective orexin 1 receptor antagonist.}^{Proc. Natl. Acad. Sci.}^{117 (30), 18059-18067 (2020).}

^3.^{Jie Yin}^{, Kuang-Yui M. Chen, Mary J. Clark, Mahdi Hijazi, Punita Kumari, Xiao-chen Bai, Roger K. Sunahara#, Patrick Barth# & Daniel M. Rosenbaum#. Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane.}^Nature^{584, 125-129 (2020).}

4. Zhenhua Shao, Wei Yan, Karen Chapman, karthik Ramesh, Aaro J. Ferrell, Jie Yin, Xuehui Wang, Qingping Xu and Daniel M. Rosenbaum. Structure of an allosteric modulator bound to the CB1 cannabinoid receptor. Nat. Chem. Biol. 15, 1199–1205 (2019).

5. Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig, Baptiste Fischer, Daniel M. Rosenbaum, Brian K. Kobilka, Els Pardon & Jan Steyaert. An improved yeast surface display platform for the screening of nanobody immune libraries. Scientific Reports 9(1): 382 (2019)

_6._{Jie Yin}_{, Karen Chapman, Lindsay D. Clark, Zhenhua Shao, Dominika Borek, Qingping Xu, Junmei Wang and Daniel M. Rosenbaum. Crystal structure of the human NK1 tackykinin receptor.}_{Proc. Natl. Acad. Sci.}_{115(52), 13264-13269 (2018).}

7. Jie Yin and Daniel M. Rosenbaum. The Human Orexin/Hypocretin Receptor Crystal Structures. Curr. Topics. Behav. Neurosci. Doi: 10.1007/7854_2016_52

_{8. Zhenhua Shao,}_{Jie Yin}_{, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang and Daniel M. Rosenbaum. High-resolution crystal structure of the human CB1 cannabinoid receptor.}_Nature_{540, 602-606 (2016).}

_9._{Yin, J.}_{, Babaoglu, K., Brautigam, C.A., Clark, L., Shao, Z., Scheuermann, T.H., Harrell, C.M., Gotter, A.L., Roecker, A.J., Winrow, C.J., Renger, J.J., Coleman, P.J. and Rosenbaum, D.M. Structures and ligand-binding mechanism of the OX1 and OX2 orexin receptor.}_{Nat. Struct. Mol. Biol.}_{23, 293-299 (2016).}

_10._{Jie Yin}_{, Juan Carlos Mobarec, Peter Kolb, and Daniel M. Rosenbaum. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.}_Nature_{519, 247-250 (2015).}