孙文智

研究员

Ph.D.

利用形态、功能和代谢等多种手段研究长期压力应激和抑郁的神经机制，探求神经与精神疾病治疗的新策略。

sunwenzhi(at)cibr.ac.cn

教育经历

1999年6月中国海洋大学海洋生物学专业，学士学位

2004年8月中国科学院神经科学研究所神经生物学专业，博士学位

工作经历

研究经历

2004年08月-2004年12月，中国科学院神经科学研究所，助理研究员

2004年12月-2010年10月，加州大学伯克利分校，博士后

2010年11月-2012年05月，杰克逊实验室（Jackson Laboratory），研究员科学家

2012年05月-2016年09月，霍华德休斯医学研究所（Howard Hughes Medical Institute）詹宁斯研究园（Janelia Research Campus），研究专员

2016年09月-2018年11月，上海科技大学 iHuman研究所，研究员

2016年09月-2018年11月，上海科技大学生命科学与技术学院，预聘助理教授

2018年12月- ，北京脑科学与类脑研究所，研究员

2020年01月- ，首都医科大学基础医学院，研究员

教学经历

2016年09月-2018年11月，上海科技大学生命科学和技术学院，预聘助理教授，（1）共同主讲与共同主持 “神经生物学基础（本科&研究生）” ；（2）主持和主讲 “光学成像基础和应用” @上海科技大学

2018、2019年秋季，参与 “PTN神经生物学（研究生）” @北京大学

2019、2020、2021年春季&秋季，参与 “神经系统疾病的分子生物学基础（研究生，本科生）” @清华大学

2019、2020、2022年春季，” 参与 “光学成像基础和应用” 课程设计和教学 @清华大学

2018、19、20、21、22，显微成像基础与应用暑期研讨会@清华大学

2022 年秋，主持和主讲光学显微镜基础和应用@北京脑科学与类脑研究中心

研究概述

实验室发展和应用活体光学成像、神经调控、遗传学标记与神经环路示踪等多项环路功能研究的前沿技术回答情感和相关精神类疾病的重要科学问题，拥有国际领先且全面的光学成像仪器（双光子显微镜、梯度折射透镜、光纤光度测量）和技术手段。也将结合单细胞测序等前沿的分子生物学手段，深入研究以下重要的神经科学问题：应激与奖赏的神经环路机制、神经药理的环路解析、神经与精神疾病治疗的新策略。

发表文章

*: first author; ^# corresponding author.

1. W Zhou*^#, S Ke*, W Li, J Yuan, X Li, R Jin, X Jia, T Jiang, Z Dai, G He, Z Fang, L Shi, Q Zhang, H Gong, Q Luo, W Sun^#, A Li^#, P Li^# (2022) Mapping the Function of Whole‐Brain Projection at the Single Neuron Level, Advanced Science 2202553.

2. C Liu, D Wang, H Zhang, W Wu, W Sun, T Zhao^#, N Zheng^# (2022) Using Simulated Training Data of Voxel-Level Generative Models to Improve 3D Neuron Reconstruction, IEEE transactions on medical imaging 2022.

3. L Liu, L Zou, K Li, H Hou, Q Hu, S Liu, J Li, C Song, J Chen, S Wang, Y Wang, C Li, Haibo Du, J-L Li, F Chen, Z Xu, W Sun, Q Sun, W Xiong^# (2022) Template-independent genome editing in the Pcdh15av− 3j mouse, a model of human DFNB23 nonsyndromic deafness, Cell Reports 40: 111061.

4. J Li, S Liu, C Song, T Zhu, Z Zhao, W Sun, Y Wang, L Song, W Xiong^# (2022) Prestin-mediated frequency selectivity does not cover ultrahigh frequencies in mice, Neuroscience Bulletin 38:769–784

5. Z Gao*, H Wang*, C Lu, S Froudist-Walsh, M Chen, X-J Wang^#, J Hu^#, W Sun^# (2021) Neural Basis of the Delayed Gratification, Science Advances 7: eabg6611.

6. N Zhang*, H Shan, M Liu, T Li, R Luo, L Yang, L Qi, X Chu, X Su, R Wang, YLiu, W Sun & Q-T Shen^# (2021) Structure and assembly of double-headed Sendai virus nucleocapsids, Communications biology 4: 1-10.

7. C Rodríguez*, A Chen*, JA Rivera, MA Mohr, Y Liang, RG Natan, W Sun, D Milkie, TG Bifano, X Chen, N Ji^# (2021). An adaptive optics module for deep tissue multiphoton imaging in vivo. Nature Methods 18: 1259-1264.

8. J Li*, S Liu*, C Song, Q Hu, Z Zhao, T Deng, Y Wang, T Zhu, L Zou, S Wang, J Chen, L Liu, H Hou, K Yuan, H Zheng, Z Liu, X Chen, W Sun, B Xiao, and W Xiong^# (2021), PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice, Proceedings of the National Academy of Sciences 118: e2101207118

9. Y* Liang, JL Fan, W Sun, R Lu, M Chen & N Ji^# (2021), A distinct population of L6 neurons in mouse V1 mediate cross-callosal communication. Cerebral Cortex 31: 4259-4273

10. J Guo*, M Ran*, Z Gao, X Zhang, D Wang, H Li, S Zhao, W Sun^#, H Dong^#, J Hu^# (2021) Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia, EBioMedicine 65: 103272.

11. S Lundt*, N Zhang, J-L Li, Z Zhang, L Zhang, X Wang, R Bao, F Cai, W Sun, W-P Ge, S Ding^# (2021) Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT. Journal of Cerebral Blood Flow & Metabolism 0271678X21992625.

12. N Xiong*^#, X Gao*, H Zhao, F Cai, F-C Zhang, Y Yuan, W Liu, F He, L G Zacharias, H Lin, H S Vu, C Xing, D-X Yao, F Chen, B Luo, W Sun, R J DeBerardinis, H Xu, W-P Ge^# (2020) Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature Communications 11: 1-9.

13. G Qiu*, Y Wu, Z Yang, L Li, X Zhu, Y Wang, W Sun, H Dong, Y Li, J Hu^# (2020), Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice. Anesthesiology 133: 377–392.

14. X Zhang*, B Lei*, Y Yuan*, L Zhang, L Hu, S Jin, B Kang, X Liao, W Sun, F Xu, Y Zhong^#, J Hu^#, H Qi^# (2020), Brain control of humoral immune responses amenable to behavioural modulation. Nature 581: 204–208.

15. X Gao*, Z Zhang, T Mashimo, B Shen, J Nyagilo, H Wang, Y Wang, Z Liu, A Mulgaonkar, X-L Hu, SGM Piccirillo, U Eskiocak, DP Davé, S Qin, Y Yang, Xi Sun, Yang-XFu, H Zong, W Sun, RM Bachoo, W-P Ge^# (2020), Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Cell Reports 30: 2489-2500.

16. Y Xiao*, H Luo, W-Z Yang, Y Zeng, Y Shen, X Ni, Shi Z, J Zhong, Z Liang, X Fu, H Tu, W Sun, WL Shen^#, J Hu ^#, J Yang^# (2020), A brain signaling framework for stress-induced depression and ketamine treatment elucidated by phosphoproteomics. Frontiers in Cellular Neuroscience 14: 48.

17. F Wang*, J Zhang, Y Yuan, M Chen, Z Gao, S Zhan, C Fan, W Sun^#, J Hu^# (2020), Salience Processing by Glutamatergic Neurons in the Ventral Pallidum. Science Bulletin 65:389-401.

18. Z-D Zhao*, Z Chen*, X Xiang*, M Hu, H Xie, X Jia, F Cai, Y Cui, Z Chen, L Qian, Ji Liu, C Shang, Y Yang, X Ni, W Sun, J Hu, P Cao, H Li^#, WL Shen^# (2019), Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nature Neuroscience 22: 921-932.

19. Y Yuan*; W Wei*; M Chen, F Cai, C Fan, WL Shen; W Sun^#; Hu, Ji^#; (2019) Reward Inhibits Paraventricular CRH Neurons to Relieve Stress, Current Biology 29: 1243-1251.

20. X-Y Su *, M Chen *, Y Yuan, Y Li, H-Q Luo, W Sun, MX Zhu, M-G Liu ^#, J Hu ^#, T-L Xu ^# (2019), Central processing of itch in the midbrain reward center. Neuron 102: 858-872

21. H Zhou*, S Zhang, F LV, W Sun, L Wang, C Fan, J Li^# & J Hu ^# (2019), Citrate‐assisted efficient local delivery of naked oligonucleotide into live mouse brain cells. Cell Proliferation 52: e12622.

22. S Zhang*, F Lv, Y Yuan, C Fan, J Li, W Sun, J Hu^# (2019), Whole-Brain Mapping of Monosynaptic Afferent Inputs to Cortical CRH Neurons. Frontiers in Neuroscience 13: e565.

23. CT Richie *, LR Whitaker, KW Whitaker, J Necarsulmer, HA Baldwin, Y Zhang, L Fortuno, JJ Hinkle, P Koivula, MJ Henderson, W Sun, K Wang, JC Smith, J Pickel, N Ji, BT Hope, BK Harvey^# (2017), Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies. Journal of Neuroscience Methods, 284: 1-14

24. R Lu*, W Sun, Y Liang, A Kerlin, J Bierfeld, J Seelig, V Wilson, B Scholl, B Mohar, M Tanimoto, M Koyama, D Fitzpatrick, MB Orger, N Ji^# (2017), Video-rate volumetric functional imaging of the brain at synaptic resolution. Nature Neuroscience, 20: 620-628.

25. W Sun*, Z Tan, BD Mensh & N Ji^# (2016), Thalamus provides layer 4 of primary visual cortex with tuned inputs. Nature Neuroscience, 19, 308-315.

26. Z Tan*, W Sun, TW Chen, DS Kim & N Ji^# (2015) Stimulus Feature Selectivity for Ultraviolet Light in Mouse Primary Visual Cortex, Scientific Reports 5: 12597.

27. K Wang*, W Sun*, CT Richie, BK Harvey, E Betzig & N Ji^# (2015), Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue. Nature Communications 6:7276.

28. C Wang*, R Liu*, D E Milkie, W Sun, Z Tan, A Kerlin, T W Chen, DS Kim & N Ji^# (2014) Multiplexed aberration measurement for deep tissue imaging in vivo. Nature Methods 11: 1037–1040

29. W Sun*, JL Wagnon, CL Mahaffey, M Briese, J Ule & WN Frankel# (2013) Aberrant Sodium Channel Activity in the Complex Seizure Disorder of Celf4 Mutant Mice. Journal of Physiology 591:241-255.

30. JL Wagnon*, M Briese*, W Sun, CL Mahaffey, Y Li, Y Curk, G Rot, D Lin, J Ule & WN Frankel^# (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genetics 8: e1003067.

31. JL Wagnon*, CL Mahaffey, W Sun, Y Yang, H T Chao & WN Frankel^# (2011) Etiology of a Genetically Complex Seizure Disorder in Celf4 Mutant Mice. Gene, Brain and Behavior 10:765-777.

32. W Sun* & Y Dan^# (2009) Layer-Specific Network Oscillation and spatiotemporal Receptive Field in the Visual Cortex, Proceedings of the National Academy of Sciences 106:17986-17991.

33. W Sun*, Q Deng* & S He^# (2006), ON direction-selective ganglion cells in the mouse retina. Journal of Physiology 576:197-202.

34. S Weng*, W Sun & S He^# (2005) Identification of ON-OFF direction-selective ganglion cells in the mouse retina. Journal of Physiology, 562: 915 – 923.

35. L Diao*, W Sun, Q Deng & S He^#(2004) Development of the mouse retina: emerging morphological diversity of the ganglion cells. Journal of Neurobiology 61: 236-249.

36. W Dong*, W Sun, Y Zhang, X Chen & S He^# (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology 556: 11-17.

37. S He^#, W Dong, Q Deng, S Weng & W Sun (2003) Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry. Science, 302:408-411. (Review)

38. W Sun*^#, N Li & S He (2002) Large-scale morphological survey of rat retinal ganglion cells. Visual Neuroscience 19:483-493.

39. W Sun*, Li N & S He^# (2002) Large-scale morphological survey of mouse retinal ganglion cells. Journal of Comparative Neurology 451:115-126.