科学研究

报告预告

小鼠大脑中细胞的分类和连接网络的刻画

    |    分享:
2019-11-20

时间:

21 / 11 / 2019

10:00-11:00

地点:

北京脑科学与类脑研究中心三楼报告厅

SPEAKER

曾红葵,博士

美国艾伦脑科学研究所执行官

HOST

井淼

ABSTRACT

为了探究大脑的生理功能以及其功能失常和脑疾病之间的关系,我们需要深入的了解大脑是由哪些不同细胞类型组成的,以及这些不同的细胞如何通过互相之间的连接实现大脑的功能调控。在Allen脑研究所,我们通过构建多系统的研究平台,包括单细胞转录组的鉴定、单细胞和多细胞的电生理记录、神经元结构的三维重构、高通量的脑连接组学的刻画以及基于成像的大尺度神经元活动观测,试图对大脑不同细胞的转录组特性、电生理特性、形态特性和连接特性进行标准流程式的精细刻画,最终期望得到对神经元进行分类并描绘它们在小鼠大脑内的互相连接方式。目前我们的工作以视觉皮层到丘脑的神经元为研究重点。这样的丰富信息将为最终解析大脑功能的内在机理提供坚实的基础。

SPEAKER BIOGRAPHY

Hongkui Zeng joined the Allen Institute for Brain Science in 2006. She currently leads the Structured Science Division to develop and operate high-throughput pipelines to generate large-scale, open-access datasets and tools to accelerate neuroscience discovery. Since joining the Allen Institute, she has also led several research programs, including the Transgenic Technology program, the Human Cortex Gene Survey project, the Allen Mouse Brain Connectivity Atlas project, and the Mouse Cell Types and Connectivity program. Zeng received her Ph.D. in molecular and cell biology from Brandeis University, where she studied the molecular mechanisms of the circadian clock in fruit flies. Then as a postdoctoral fellow at Massachusetts Institute of Technology, she studied the molecular and synaptic mechanisms underlying hippocampus-dependent plasticity and learning. Her current research interests are in understanding neuronal diversity and connectivity in the mouse visual cortical circuit and how different neuronal types work together to process and transform visual information. She has broad scientific experience and a keen interest in using a combined molecular, anatomical and physiological approach to unravel mechanisms of brain circuitry and potential means for treating brain diseases.