科学研究

报告预告

小鼠视前区通过产生温度依赖的PGD2调节温度

    |    分享:
2019-10-30

Chinese Institute for Brain Research, Beijing

 Seminar

Seminar Type

B-type

Preferred Location

Third Floor Lecture Hall, Jianzan Building (Phase I)

Chinese Institute for Brain Research, Beijing

Time

14:00-15:00pm  WednesdayOctober 30th, 2019

Speaker

Tongfei Wang, Ph.D.

Postdoc

University of California, San Francisco



王同飞,博士

加州大学旧金山分校博士后

 temp4cj.png

Host

Dr. Minmin Luo

Topic

Thermoregulation via Temperature-dependent PGD2 Production in Mouse Preoptic Area


小鼠视前区通过产生温度依赖的PGD2调节温度

Abstract

Single-cell RNA-seq combined with whole-cell patch-clamp recording identifies PGD2 synthase enriched in temperature-sensitive neurons in the medial preoptic area of mouse, which detects brain temperature increase and mediates body temperature decrease via PGD2 receptor DP1 expressed in ventral medial preoptic area.

摘要

把单细胞转录组测序和全细胞膜片钳记录两种技术结合在一起发现在小鼠内侧视前区对温度敏感的神经元内富集了PGD2合成酶,这些神经元可检测脑温的升高进而通过在腹内侧视前区表达PGD2的受体DP1使体温降低。

Speaker

Biography

EDUCATION

Aug 2012        Ph.D. in Molecular and Integrative Physiology

University of Illinois at Urbana-Champaign

Thesis: Circadian Rhythms of Redox State and the Regulation of Neuronal Excitability in Suprachiasmatic Nucleus of Rodents

 

July 2005         B.S. in Biological Science

Peking University

Thesis: Intracellular Mechanism of the Spontaneous Calcium Oscillations in Rat Hippocampal Astroctrocytes

 

RESEARCH EXPERIENCE

Aug 2012–present     Postdoc Scholar, University of California, San Francisco (Advisor: Dr. Lily Y. Jan)

Jan 2006 – July 2012    Graduate Research Assistant, University of Illinois at Urbana-Champaign (Advisor: Dr. Martha U. Gillette )

July 2003 – Jun 2005     Undergraduate Research Assistant, Peking University (Advisor: Dr. Shiqiang Wang)