Chinese Institute for Brain Research, Beijing
10:00-11:00 Monday，September 2nd , 2019
Xiangmin Xu, Ph.D.
Department of Anatomy and Neurobiology
School of Medicine
University of California, Irvine
Dr. Fei Zhao
applications of the latest technologies of neuroscience in mapping hippocampal neural circuits related to spatial learning and memory. He will discuss insights from their studies of cortico-hippocampal circuitry associated with subiculum (SUB) projections to CA1. Specifically, their recent work has identified a distinct sub-population of SUB neurons forming a pathway from visual cortex to CA1 and perirhinal cortex, and demonstrated that this pathway plays a critical role in object-place learning. These findings in hippocampal circuit mechanisms provide an intriguing new target to counteract Alzheimer's Disease (AD)-related memory impairments. The Xu lab is currently working to determine whether spatial memory can be rescued by patterned stimulation of the non-canonical subiculum-CA back-projection in AD model mice.
分子遗传学、病毒学和成像技术的新进展为研究神经环路的结构和功能提供了强大的工具。在这次报告中，徐博士将分享其团队应用最新技术解析与空间学习记忆相关的海马神经环路，尤其是与皮层-海马环路有关的海马下托（subiculum，SUB）到CA1的投射连接。具体而言，他们最近的工作鉴定出了SUB神经元的一个独特的亚群可以形成从视觉皮层到CA1及嗅缘皮层 (perirhinal cortex) 的投射，并且证明该环路在物体-空间位置学习中起着关键作用。这些海马环路机制中的新发现为改善阿尔茨海默病（AD）相关的记忆障碍提供了一个新的有力目标。徐博士实验室目前正在研究是否可以通过刺激非经典SUB-CA神经环路来恢复AD模型小鼠的空间记忆。
08/1998-02/2004 Ph.D., Psychology/Neuroscience, Vanderbilt University
09/1995-06/1998 M.S., Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences
09/1990-06/1995 Bachelor of Medicine, Shanghai Medical University, Shanghai China
I have a strong background in biology, engineering and medicine that I have applied to answering fundamental questions in neuroscience. My interests focus on neural circuit organization and function, in relation to the neurobiology of sensory perception, learning and memory, and stress. We use a multidisciplinary approach that combines electrophysiology, photostimulation and optical imaging, molecular genetics and viral tracing. Our analysis is further refined and informed by engineering and computational techniques. Our achievements are reflected by our publications in high impact journals, and my receipt of prestigious awards as an independent investigator. I have been a Principal Investigator for multiple NIH and private foundation grants. I have active collaborations with many other successful investigators at UC Irvine and at other major research institutions in southern California and elsewhere in the US.