Eric Alexander Miska：
Third Floor Lecture Hall, Jianzan Building (Phase I)
Chinese Institute for Brain Research, Beijing
10:00-11:00 Tuesday，August 13th, 2019
Eric Alexander Miska, Ph.D
Herchel Smith Professor of Molecular Genetics,
Department of Genetics, University of Cambridge
Fellow and Director of Studies in Molecular Biology,
St. John’s College, Cambridge
Wellcome Sanger Institute
Founder and Director,
STORM Therapeutics Ltd
Dr. Magdalena J Koziol
RNA: from structure and chemical modification to new functions
The genome is transcribed into RNA. Some RNA encodes protein. More RNA acts directly in the control of gene expression. My group is studying such RNA control mechanisms. To do this we are using a variety of tools from chemical biology to cell biology and from computation to animal genetics. Recent work has focused on (i) in vivo RNA structure determination, (ii) RNA modification of tRNA and mRNA as a new layer of control, (iii) RNA and transposon control and (iv) RNA-mediated inheritance. While our work is of a fundamental nature it impinges on human disease such as viral infection, metabolic disease and cancer. I will present unpublished work from the group.
Eric Alexander Miska，博士
剑桥大学遗传系 分子遗传学系Herchel Smith冠名教授
Studying mathematics, physics and biology at Heidelberg, Berlin and Mainz he received a BA in Biochemistry from Trinity College, Dublin, in 1996. While a PhD student with Tony Kouzarides he characterised a novel class of histone deacetylase enzymes and received a PhD in pathology from the University of Cambridge, UK in 2000.
As a postdoc with Bob Horvitz at the Massachusetts Institute of Technology he studied the then newly-discovered class of miRNA genes in the nematode C. elegans as a major functional genomics project. He also developed the first miRNA microarray which led to the first map of miRNA expression in human cancer.
Since establishing his own research group in 2005 at the Gurdon Institute he has continued to investigate gene regulation by non- coding RNA and other epigenetic mechanisms. Highlights include assigning biological function to some of the first animal miRNAs. Next they discovered the piRNA pathway in C. elegans. They also demonstrated that the piRNA pathway of C. elegans functions upstream of a nuclear RNAi pathway. They showed that piRNAs and nuclear RNAi lead to a mutigenerational RNA memory in C. elegans. Together with their collaborators they discovered the first virus to naturally infect C. elegans. Thus having a new host-pathogen paradigm in hand they were able to demonstrate that RNA interference provides immunity to natural viral infection in animals. They also identified an RIG-I homologue (mammalian interferon response), and an RNA-modifying enzyme (Tutase) as majoring conserved determinants of viral sensitivity. More recently they made significant contributions to our understanding of RNA structure and chemical modification in vivo including the discovery of a novel RNA modification in eukaryotes (together with Shankar Balasubramanian).
They also led a major collaborative effort to "re-invent" African cichlids as a vertebrate model for the study of non-DNA based inheritance. Currently the Herchel Smith Professor of Molecular Genetics and Deputy Director of the Gurdon Institute, he is also the 2013 recipient of the Hooke Medal awarded by the British Society of Cell Biology. A full member of EMBO since 2012 their work on RNA-modifying enzymes has led him to found a Cambridge University spin-out company, STORM Therapeutics Limited, which aims to deliver new medicines by targeting RNA in cancer.