科学研究

学术报告

气味感知发育的关键期:分子机制和行为效应 | CIBR Seminar

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2019-07-17

俞从容

发育关键期是指发育过程中感官体验能够对神经连接和环路功能产生持续影响的时间窗口。在哺乳动物中,嗅觉系统是唯一能够在动物的整个生命过程中持续产生新神经元的神经系统。这种独特的特征说明嗅觉神经元可能掌握着其他神经元丢失再生能力的秘密。在这种再生神经系统中,我们发现了感觉神经元与其中枢连接之间形成高度特异性联系的关键时期。尽管在出生后发育过程会生成大量神经元,我们发现只有一群围产期感觉神经元具有形成嗅觉地图的能力,能够纠正错误的轴突投射。在这里,我将讨论嗅觉系统形成过程中关键期的行为学效应,鉴别关键期导航神经元,导航神经元建立嗅觉地图的细胞机制,以及控制关键期发生时机的分子机制。

俞从容,1990年于清华大学获得学士学位,1996年美国哥伦比亚大学获得博士学位,之后在诺贝尔奖得主Richard Axel实验室工作。现为美国堪萨斯大学副教授,Stowers研究所研究员。主要领域为嗅觉神经生物学,嗅觉和信息素的信号传导、编码及神经回路,发育关键期的分子基础及干细胞分化。在Nature、Science、Cell、PNAS、Nature Communications、 Neuron、Current Biology、 eLife 、Journal of Neuroscience 等国际著名学术期刊发表论文31篇。目前同时获得3个R01基金的资助。担任美国国立卫生院、美国国家科学基金会、HFSP、意大利卫生部、美国-以色列联合科学基金委等基金的评审专家,Nature、Science、Cell、PNAS等国际著名学术期刊的审稿专家。获得“荧光鼠模型”等三项专利。

Seminar 

TypeB-type

Preferred Location

First Floor Lecture Hall, Jianzan Building (Phase I)

Chinese Institute for Brain Research, Beijing

Time

10:30-11:30 am Friday,July 19, 2019 

Speaker

Congrong “Ron” Yu, Ph.D

Investigator

Stowers Institute for Medical Research

Associate Professor

Department of Anatomy & Cell Biology
The University of Kansas School of Medicine

俞从容,博士

斯托尔斯医学研究所研究员

堪萨斯大学医学院解剖学与细胞生物学系副教授

Host

Dr. Minmin Luo

Topic

Critical Period in the Development of the Sense of Smell: Mechanisms and Behavioral Consequences

气味感知发育的关键期:分子机制和行为效应

Abstract

The critical period is a developmental window during which sensory experience have lasting impact on the anatomical connection and functions of neural circuits. In the mammalian species, the olfactory system is the only nervous system that continuously generate new neurons throughout the life of the animals. This unique characteristic suggests that the olfactory neurons may hold a secret of regenerative capacity that is lost in other neurons. In this regenerative nervous system, we discover a critical period in setting up the highly specific connections between sensory neurons and their central targets. Despite massive neurogenesis during the postnatal development, we found only a population of perinatally born sensory neurons are endowed with the ability to set the olfactory map, and to correct erroneously projecting axons. Here I will discuss the behavioral implication of a critical period in the olfactory system development, the identification of a population of navigator neurons during the critical period, the cellular mechanisms by which the navigators establish the olfactory map, and the molecular mechanism that control the timing of the critical period