科学研究

PI

饶毅 中心主任、资深研究员、教授

电子邮件: yrao@pku.edu.cn

电话: +86-10-80765601

实验室主页: http://www.raolab.org/

教育经历

1991年-1994年    哈佛大学生物化学和分子生物学系,博士后

1985年-1991年    旧金山加州大学生理系神经科学,博士

1983年-1985年    上海第一医学院,硕士研究生

1978年-1983年    江西医学院,本科生

工作经历

现任:北京脑科学与类脑研究中心主任,北京大学终身讲席教授、理学部主任、校务委员会副主任,北大-清华生命科学联合中心主任,北大-IDG/麦戈文脑研究所所长

曾任:北京大学生命科学学院院长,美国西北大学医学院Elsa Swanson 讲席教授,神经科学研究所副所长,华盛顿大学医学院神经生物学助理教授、副教授、教授

研究概述

在神经发育方面,曾发现控制神经发育的基因,阐明眼睛发育的起源,揭示神经导向分子及其信号转导机理。

目前集中研究行为的分子和细胞机制

针对动物,使用遗传学、分子生物学和生物物理学手段,提出化学连接组概念,依据神经系统化学传递特色,设计化学连接组学,通过系统地进行基因敲除和敲入建构化学连接组学的工具库,通过现代成像技术揭示已知递质的神经环路,通过特异启动子相关操纵及其逻辑门在功能上研究神经细胞及其关系,从而研究参与行为的神经信号和环路。

针对人类,使用遗传学、基因组学和脑成像(fMRI)方法,研究人类行为和认知重要的基因和脑区,通过研究人类特有的机制帮助理解自身。

发表文章

1) Rao Y, Jan LY, and Jan YN (1990). Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins. Nature 345:163-167.

 

2) Li HS, Tierney C, Wen L, Wu JY and Rao Y (1997). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal mesoderm. Development 124:603-615.

 

3) Li HS, Chen JH, Wu W, Fagaly T, Yuan WL, Zhou L, Dupuis S, Jiang Z, Nash W, Gick C, Ornitz D, Wu JY, and Rao Y (1999). Vertebrate Slit, a secreted ligand for the transmembrane protein Roundabout, is a repellent for olfactory bulb axons. Cell 96:807-818.

 

4) Wu W, Wong K, Chen JH, Jiang ZH, Dupuis S, Wu JY, and Rao Y (1999). Directional guidance of neuronal migration in the olfactory system by the secreted protein Slit. Nature  400:331-336.

 

5) Zhu Y, Li HS, Zhou L, Wu JY, and Rao Y (1999). Cellular and molecular guidance of GABAergic neuronal migration from an extra-cortical origin to the neocortex. Neuron 23: 473-485.

 

6) He M, Wen L, Campbell C, Wu JY, and Rao Y (1999). Transcription repression by ET, an ortholog of human Tbx3, a gene involved in ulnar-mammary syndrome. Proc. Natl. Acad. Sci. USA 96:10212-10217.

 

7Wu JY, Feng L, Park H-T, Havlioglu N, Wen L, Tang H, Bacon KB, Jiang Z, Zhang X-C, and Rao Y (2001). The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410:948-952.

 

8) Wong K, Ren X-R, Huang Y-Z, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong W-C, and Rao Y (2001). Signal transduction in neuronal migration: rof GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107:209-221.

 

9) Zhu Y, Yu T, Zhang X-C, Nagasawa T, Wu JY, and Rao Y (2002). Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons. Nature Neurosci. 5:719-720.

 

10) Ward M, McCann C, DeWulf M, Wu JY and Rao Y (2003). Distinguishing between directional guidance and motility regulation in neuronal migration. J Neurosci 23:5170-5177.

 

11) Liu G and Rao Y (2003). Neuronal migration from the forebrain to the olfactory bulb requires a new attractant persistent in the olfactory bulb. J Neurosci 23:6651– 6659.


12) Ward ME, Wu JY and Rao Y (2004). Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells. Proc Natl Acad Sci USA 101:970-974.


13) Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu JY, and Rao Y (2004). Netrin requires the focal adhesion kinase and the Src family kinases to induce axon outgrowth and to attract axons. Nature Neurosci 7:1222-1232.

 

14) Jiang H, Guo W, Liang XH, and Y Rao (2005). Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3 and its upstream regulators. Cell 120:123-135.

 

15) Li X, Gao X, Liu G, Xiong W, Wu J, and Rao Y (2008). Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nature Neurosci 11:28-35.

 

16) Zhou C, Rao Y, and Rao Y (2008). A subset of octopaminergic neurons are important for Drosophila aggression. Nature Neurosci 11:1059-1061.

 

17) Liu Y, Jiang Y, Si Y, Kim J-Y, Chen Z-F, and Rao Y (2011). Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brain of male mice. Nature 472:95-99.

 

18) Liu WW, Liang XH, Li YN, Gong JX, Yang Z, Zhang YH, Zhang JX  and Rao Y (2011). Social regulation of aggression mediated by pheromonal activation of Or65a olfactory receptor neurons in Drosophila. Nature Neurosci 7:896-902.

 

19) Zhou C, Huang H, Kim SM, Lin H, Meng X, Chiang A-S, Wang JW, Jiao R, Rao Y (2012) Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning. J Neurosci 32:14281-14287.

 

20) Zhang SS, Liu Y, Rao Y (2013). Serotonin signaling in the brain of adult female mice is required for sexual preference. Proc Natl Acad Sci USA 110:9968-9973.

 

21) Qian YJ, Cao Y, Deng BW, Yang G, Li J, Xu R, Zhang D, Huang J and Rao Y (2017). Sleep homeostasis regulated by 5HT2b receptor in a small subset of neurons in the dorsal fan-shaped body of Drosophila. eLife doi.org/10.7554/eLife.26519.001.

 

22) Zhang X, Yan HM, Huang ZL and Rao Y (2018). Independence of 5HT involvement in sleep and arousal from thermoregulation in mice. Mol Pharmacol 93:657-664.