科学研究

PI

孙文智 PI

电子邮件: sunwenzhi@cibr.ac.cn

电话: +86-10-62756185

实验室主页:

教育经历

1999年6月,获得中国海洋大学海洋生物学专业学士学位

2004年8月,获得中国科学院神经科学研究所神经生物学专业博士学位

工作经历

2004年08月-2004年12月,中国科学院神经科学研究所,助理研究员

2004年12月-2010年10月,加州大学伯克利分校,博士后研究工作

2010年11月-2012年05月,杰克逊实验室(Jackson Laboratory),研究员科学家

2012年05月-2016年09月,霍华德休斯医学研究所(Howard Hughes Medical Institute)詹宁斯研究园区(Janelia Research Campus),研究专员

2016年09月-2018年11月,上海科技大学iHuman研究所,PI

2018年12月- ,北京脑科学与类脑研究中心,PI,研究员


研究概述

实验室发展和应用活体光学成像、神经调控、遗传学标记与神经环路示踪等多项环路功能研究的前沿技术回答情感和相关精神类疾病的重要科学问题,拥有国际领先且全面的光学成像仪器(双光子显微镜、梯度折射透镜、光纤光度测量)和技术手段。也将结合单细胞测序等前沿的分子生物学手段,深入研究以下重要的神经科学问题:应激与奖赏的神经环路机制、神经药理的环路解析、神经与精神疾病治疗的新策略。

发表文章

1. Richie CT, Whitaker LR, Whitaker KW, Necarsulmer J, Baldwin HA, Zhang Y, Fortuno L, Hinkle JJ, Koivula P, Henderson MJ, Sun W, Wang K, Smith JC, Pickel J, N Ji, Hope BT, Harvey BK (2017), Near-infrared fluorescent protein iRFP713 as a reporter protein for optogenetic vectors, a transgenic Cre-reporter rat, and other neuronal studies. Journal of Neuroscience Methods, 284, 1-14

2. Lu R, W Sun, Liang Y, Kerlin A, Bierfeld J, Seelig J, Wilson V, Scholl B, Mohar B, Tanimoto M, Koyama M, Fitzpatrick D,Orger MB, Ji N (2017), Video-rate volumetric functional imaging of the brain at synaptic resolution. Nature Neuroscience, 20, 620-628.

3. Sun W, Tan Z, Mensh BD & Ji N (2016), Thalamus provides layer 4 of primary visual cortex with tuned inputs. Nature Neuroscience, 19, 308-315.

Highlighted by HHMI Research News (https://www.hhmi.org/news/adaptive-optics-helps-reveal-what-eyes-tell-brain)

4. Tan Z, Sun W, Chen TW, Kim D & Ji N (2015) Stimulus Feature Selectivity for Ultraviolet Light in Mouse Primary Visual Cortex.  Scientific Reports, 5: 12597. doi: 10.1038/srep12597.

5. Wang K#, Sun W#, Richie CT, Harvey BK, Betzig E & Ji N (2015), Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue. Nature Communications, 6:7276. doi: 10.1038/ncomms8276. (# Co-first-author)

6. Wang C, Liu R, Milkie DE, Sun W , Tan Z, Kerlin A, Chen TW, Kim DS & Ji N (2014) Multiplexed aberration measurement for deep tissue imaging in vivo. Nature Methods, 11: 1037–1040

7. Sun W, Wagnon JL, Mahaffey CL, Briese M, Ule J & Frankel WN (2013) Aberrant Sodium Channel Activity in the Complex Seizure Disorder of Celf4 Mutant Mice. Journal of Physiology, 591:241-255, (Highlighted in Future Neurology, 8(3):255-257, DOI 10.2217/fnl.13.13)

8. Wagnon JL, Briese M, Sun W, Mahaffey CL, Li Y, Curk Y, Rot G, Lin D, Ule J & Frankel WN (2012) CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genetics, 8 (11), e1003067

9. Wagnon JL, Mahaffey CL, Sun W, Yang Y, Chao HT & Frankel WN (2011) Etiology of a Genetically Complex Seizure Disorder in Celf4 Mutant Mice. Gene, Brain and Behavior, 10:765-777

10. Sun W & Dan, Y (2009) Layer-Specific Network Oscillation and spatiotemporal Receptive Field in the Visual Cortex, Proceedings of the National Academy of Sciences, 106:17986-17991.

11. Sun W#, Deng Q# & He S (2006), ON direction-selective ganglion cells in the mouse retina. Journal of Physiology, 576:197-202. (# Co-first-author)

12. Weng S, Sun W & He S (2005) Identification of ON-OFF direction-selective ganglion cells in the mouse retina. Journal of Physiology, 562: 915 – 923.

13. Diao L, Sun, W Deng Q & He S (2004) Development of the mouse retina: emerging morphological diversity of the ganglion cells. Journal of Neurobiology, 61: 236-249.

14. Dong W, Sun W, Zhang Y, Chen X & He S (2004) Dendritic relationship between starburst amacrine cells and direction-selective ganglion cells in the rabbit retina. Journal of Physiology, 556: 11-17.

15. He S, Dong W, Deng Q, Weng S & Sun W (2003) Seeing More Clearly: Recent Advances in Understanding Retinal Circuitry. Science, 302:408-411. (Review)

16. Sun W, Li N & He S (2002) Large-scale morphological survey of rat retinal ganglion cells. Visual Neuroscience, 19:483-493. 

17. Sun W, Li N & He S (2002) Large-scale morphological survey of mouse retinal ganglion cells. Journal of Comparative Neurology, 451:115-126.